Saturday February 9, 2008
Adjuvant treatment in Ethylene Glycol toxicity


Q: Which 2 very easily available and cost-effective drugs should be added as an adjuvant treatment in Ethylene Glycol toxicity (though mostly forgotten) ?



A: Thiamine 100 mg IV daily and Pyridoxine 100 mg IV daily

One of the metabolite of Ethylene Glycol is Glycolic acid which converts into Glycoxylic Acid and remains toxic. Thiamine and Pyridoxine converts Glycoxylic Acid into non-toxic metabolites and decreases long term toxic effects of Ethylene Glycol.


Related previous pearl:

Ethanol drip in Ethylene Glycol toxicity

Treating Ethylene Glycol poisoning